Bowenoid papulosis is manifested by clinically the benign-appearing papules of anogenital region and histopathologically similar features of squamous cell carcinoma in situ in human. A cause is thought to be Human Papillomavirus infection, type
16.
the
treatment is mainly through conservative management but others are topical application of 5-FU ointment and subcutaneous injection of recombinant interferon gamma.
We present a case of Bowenoid papulosis treated with DNCB immunotherapy. The patient had multiple papules on the penis with mild pruitus. Histopathologic findings showed crowding and irregular arrangement of the nuclei, many of which are large,
hyperchromatic, and pleomorphic. Dyskeratotic and multinucleated keratinocytes were also present, as were atypical mitoses, scattered in epidermal layer. We treated him with DNCB immunotherapy. Initially he was sensitized with 2,000 ㎍/0.1ml and
two
weeks later he received 50㎍/0.1ml per every week. After 3 weeks, he had showed no improvement and we levated the dos to 100㎍/0.1ml. He was improved after 6th trial and his skin lesions were almostly disappeared at present. (Kor J Dermatol
1992;30(5):669-673)
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